Intracavernous injection of linsidomine chlorhydrate in monkeys : Lack of toxic effect with long-term use

Objective : We sought to investigate whether linsidomine chlorhydrate (SIN1, the active metabolite of molsidomine and a nitric oxide donor) has a toxic effect when used chronically for the treatment of impotence. Methods : We gave 50 intracavernous injections of 1.5 mg SIN 1 over 25 weeks to each of 5 monkeys. Results : Four monkeys consistently responded with erections of sufficient rigidity and duration (mean 47.5 ± 3.3 min), and none of the five evidenced histopathologic changes of the cavernous tissue. Conclusion : SINI appears to be a safe option for the pharmacotherapy of erectile dysfunction.