Intercannabinoid and cannabinoid-ethanol interactions and their effects on human performance

The cannabinoids (THC, 215 μ/kg; CBD, 320 μg/kg; CBN, 320 μg/kg) and ethanol (0.54 g/kg) were administered orally to human volunteers alone and in all possible combinations and performance decrements were assessed on a battery of tests (standing steadiness, simple and complex reaction times, pursuit rotor and Vienna Determination Apparatus) over a 280 min period. Blood ethanol concentrations and pulse rates were measured, an assessment was made of conjunctival hyperaemia and the subjects were asked to estimate the nature and degree of their intoxication.