Abstract 10900: Persistent Alterations in Energy Metabolism and Oxygen Consumption Following Cardiac Arrest

Introduction: Although metabolic problems after cardiac arrest (CA) have been postulated, the actual measurement of metabolic alterations after CA remain undescribed. The measurement of oxygen extraction (VCO2), carbon dioxide excretion (VCO2), and respiratory quotient (RQ), reflect the energy metabolism and may provide insight into the post-arrest metabolism. Objective: To investigate metabolism alterations after CA, which may be detected via changes in VCO2, VO2, and RQ. Secondarily to test whether it is affected by therapeutic temperature management (TTM) Methods: Sixteen male rats underwent a protocol for 10 minutes of asphyxial CA and return of spontaneous circulation (ROSC). Three groups were compared: Group1: controls (no-CA, n=5), group2: CA (n=6), and group3: CA with TTM (n=5). Within the TTM group, the body was cooled to 33 °C. Capnography was recorded and O2 extraction was measured for 120min to measure VCO2 and VO2. RQ was the ratio of VCO2/VO2. Results: The post arrest VCO2 was 1.5 fold highe...