[Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism].

Objective: To observe the effect of psoralidine in rats with ovariectomy,and preliminarily study its mechanism.Method: Sixty female Sprague-Dawley rats were divided into 5 groups: the sham operation group,the model group,the psoralidine low-dose group(4 mg·kg-1),the psoralidine high-dose group(16 mg·kg-1) and the Zhuangguzhitong capsule group,with 12 rats in each group.Thirteen weeks later,their blood and bone samples were collected to detect bone density,bone biochemistry,pathomorphology,serum E2 and CT.Result: Psoralidine could up-regulate the bone density of lumbar vertebra and thighbone of rats with ovariectomy(P0.05),the maximum bending strength of thighbone(P0.05),and serum E2 and CT(P0.05).Conclusion: Psoralidine has a good active effect on postmenopausal antiosteoporosis.Its mechanism may be related to such pathways as E2 and CT.