Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo

Yue Wu,Ping Song,Wencheng Zhang,Junhui Liu,Xiaoyan Dai,Zhaoyu Liu,Qiulun Lu,Changhan Ouyang,Zhonglin Xie,Zhengxing Zhao,Xiaozhen Zhuo,Benoit Viollet,Marc Foretz,Jiliang Wu,Zuyi Yuan,Ming-Hui Zou

Activation of AMPKα2 in adipocytes is essential for nicotine-induced insulin resistance in vivo

2015

Yue Wu
Ping Song
Wencheng Zhang
Junhui Liu
Xiaoyan Dai
Zhaoyu Liu
Qiulun Lu
Changhan Ouyang
Zhonglin Xie
Zhengxing Zhao
Xiaozhen Zhuo
Benoit Viollet
Marc Foretz
Jiliang Wu
Zuyi Yuan
Ming-Hui Zou

Nicotine acts on adipocytes to induce activation of AMPK, promoting excess lipolysis and weight loss but also the development of whole-body insulin resistance.

Keywords:

Nicotine
Protein kinase B
Insulin resistance
AMP-activated protein kinase
Lipolysis
AMPK
Enzyme activator
Endocrinology
Internal medicine
Insulin Receptor Substrate Proteins
Medicine

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