Method for preparing rilpivirine hydrochloride isomer Z and impurity X and application of impurity X as pesticide in agriculture

2018 
The invention relates to the field of pharmaceutical chemistry synthesis, and relates to a method for preparing rilpivirine hydrochloride isomer Z and impurity X and application of impurity X as a pesticide in agriculture. The isomer Z has a structure represented by formula (I): the impurity X has a structure shown in (II): the rilpivirine hydrochloride isomer Z or the impurity X or the combination thereof is obtained by separating from reaction liquid during rilpivirine preparation. The invention improves the impurity spectrum of rilpivirine hydrochloride and has extremely important significance for realizing the quality control of rilpivirine hydrochloride and preparations thereof.
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