Effect of Different Doses of Vitamin E with Selenium on Renal Damage Caused by Unilateral Ureteral Obstruction Model

Objective: Chronic kidney disease CKD is still common worldwide. We investigated the effect of two different doses of vitamin E with selenium Se administration to prevent CKD leads to renal damage via unilateral ureteral obstruction UUO . Material and Methods: Thirty-two female Wistar Albino rats were divided into four groups; a sham group left UUO+no medication ; left UUO with no treatment, left UUO treated with 100 mg/kg dose Vitamin E+Se RPVE+Se and left UUO treated with 1000 mg/kg Vitamin E+Se HDVE+Se mixture. All rats subjected during 14 days and killed humanely. Malondialdehyde MDA , superoxide dismutase SOD , glutathione GSH , levels were determined in kidney tissue, whereas total antioxidant status TAS , total oxidant status TOS and DNA damage marker 8-hydroxy-2-deoxyguanosine 8-OHdG in serum. Histologic examination were also done. Results: The unilateral ureteral obstruction model increased MDA p