Iloprost: a potential alternative for skin graft-resistant hypertensive leg ulcer.

Hypertensive leg ulcer (HLU) is a painful chronic ulcer of the leg with necrotic and livedoid margins that develops rapidly.(1,2,) It mainly affects patients with diabetes mellitus or arterial hypertension.(3) The pathophysiology involves microvascular ischemia.(2) Management of HLU involves control of comorbidities, wound debridement, dressings and analgesics (morphine). Surgical management with grafts is recommended to control pain and promote healing.(4,5) However, with treatment failure, there are unmet therapeutic needs.