N THE BIOSYNTHESIS OF PROSTAGLANDINS Fla AND F

Cus-+, added to enzyme preparations from vesicular gland stimulates the produc- tion of prostaglandins F. This is further enhanced by addition of dithiols, which pre- sumably provide reducing equivalents to convert the intermediate endoperoxide to the dial, F, derivative. The increased yield of prostaglandins F is accompanied by decreased amounts of prostaglandins E, confirming the concept of a common intermediate in the biosynthesis of the two types of prostaglandin.