PS1:4 Searching biomarkers in lupus nephritis by proteomics

Introduction Lupus nephropathy (NL) is an important cause of morbidity and mortality in patients with SLE. The objective of the renal biopsy is to determine the type of glomerulonephritis that the patient presents to be treated. A proteomics study is proposed to determine biomarkers that help us to differentiate patients diagnosed with SLE with and without renal involvement. Objective To determine if there are a different patron of proteins between patients diagnosed with SLE with and without renal involvement. Methods We selected 12 patients diagnosed with SLE with renal involvement and 14 patients diagnosed with SLE without renal involvement. A 24 hour urine sample was obtained for analysis. Results A total of 292 proteins (identified with at least two peptides with a FDR Conclusion A different protein pattern is observed between the two groups of patients, so in a more detailed study we can indicate if some of these can serve as prognostic markers for this type of patients.