Study of p53 and bcl-2 Oncoproteins in Ulcerative Colitis with Dysplasia

Background Dysplasia in ulcerative colitis has been graded on haematoxylin and eosin stain using Riddle's criteria. This system was formed to nullify the inter-observer variation. Few cases of early dysplasia were missed when purely screened on morphology. This study was carried out to detect early dysplasia using p53 and bcl-2 oncoproteins.