New ghrelin agonist, HM01 alleviates constipation and L‐dopa‐delayed gastric emptying in 6‐hydroxydopamine rat model of Parkinson's disease

Hiroshi Karasawa,Claudio Pietra,C. Giuliano,S. García Rubio,X. Xu,Seiichi Yakabi,Yvette Taché,Lixin Wang

New ghrelin agonist, HM01 alleviates constipation and L‐dopa‐delayed gastric emptying in 6‐hydroxydopamine rat model of Parkinson's disease

2014

Hiroshi Karasawa
Claudio Pietra
C. Giuliano
S. García Rubio
X. Xu
Seiichi Yakabi
Yvette Taché
Lixin Wang

Background Constipation and L-dopa-induced gastric dysmotility are common gastrointestinal (GI) symptoms in Parkinson’s disease (PD). We investigate the novel ghrelin agonist, HM01 influence on GI motor dysfunctions in 6-hydroxydopamine (6-OHDA) rats.

Keywords:

Ghrelin
Levodopa
Parkinson's disease
Agonist
Gastroenterology
Hydroxydopamine
Endocrinology
Constipation
Oxidopamine
Internal medicine
Diabetes mellitus
Medicine
gastric emptying

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