Synthesis of α-haloenamides via zinc halide mediated direct addition of benzhydryl halides to ynamides
2016
A regio- and stereoselective synthesis of highly substituted α-haloenamides was described via the zinc halide mediated direct addition of benzhydryl halides to ynamides under mild conditions. The products α-haloenamides were further transformed into multisubstituted enamides via Suzuki and Sonogashira cross-coupling reactions.
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