Мониторинг концентрации клозапина и норклозапина при терапии шизофрении

The article discusses therapeutic drug monitoring (TDM) data for clozapine obtained in patients with various forms of schizophrenia undergoing treatment in hospital. Clozapine and its metabolite norclozapine concentrations and their response to the administered drug doses have been studied. Clozapine and norclozapine assay in human blood has been performed by high performance liquid chromatography with mass spectrometric detection. Monitoring and subsequent data analysis has been supported with necessary clinical information in the form of special requests - TDM cards. The obtained data on concentration levels have been arranged as follows: 38.64 % within therapeutic range, 38.64 % within subtherapeutic range (<350 ng/ml) and 22.73 % within arbitrary toxic range (600 ng/ml) when administering 25 to 30 mg of clozapine daily. Average concentrations of clozapine and norclozapine were higher in non-smokers compared to smokers.