Relation of vascular and osseous changes in leprosy

1978 
Bilateral lower limb angiography was performed on 58 patients with leprosy. Ischemia to the anesthetic feet with delay in circulation and constricted vessels were demonstrated. Further compromise of the restricted blood flow, due to abnormal arteriovenous shunting in thigh and calf muscles or to the inflammatory granulomas of the foot sole, was noted. These vascular abnormalities associated with abnormal granulomatous areas in the sole were seen to precede and influence the pathologic skeletal changes of the lower extremities and feet.
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