Effect of short-term insulin pump therapy on oxidative stress in patients with newly diagnosed type 2 diabetes

Objective To investigate the effect of short-term insulin pump therapy and multiple subcutaneous injection of insulin on 8-iso-prostaglandin F2α and C-reactive protein in newly diagnosed type 2 diabetes patients. Methods Sixty patients newly diagnosed with type 2 diabetes were randomly divided into two groups. The patients were given insulin pump therapy in CSII group and multiple subcutaneous injection of insulin in MSII group for 2 weeks. Fasting plasma glucose( FPG),2-hour postprandial blood glucose( 2 hPG),fasting C-peptide( C-P),2-hour postprandial C-peptide( 2 hC-P),glycated hemoglobin( HbA1c),blood 8-iso-prostaglandin F2α, C-reactive protein( CRP) and other changes were compared before and after treatment. Results After treatment,FPG,2hPG,HbA1c, 8-iso-prostaglandin F2α,and CRP decreased significantly in two groups( P 0. 05),and FC-P,2 hCP were significantly increased( P 0. 05). The difference of FPG,2 hPG,CP,2 hC-P,8-iso-prostaglandin F2α,CRP before and after treatment were significantly higher in CSII group than that in MSII group( P 0. 05). The amount of insulin was significantly reduced in CISS group than that in MISS group. Conclusion Compared with multiple subcutaneous injection of insulin,short-term intensive insulin pump therapy not only keep stable blood glucose and improve β-cell function and insulin resistance,but also could improve the oxidative stress and reduce the inflammation.