Synthesis and immunomodulating properties of poly(N-vinylformamide)

A series of poly(N-vinylformamide) (PNVF) samples with molecular masses in the range (8.7 – 280) × 103 were synthesized. The effect of the polymer molecular mass on the PNVF-stimulated antibody response was investigated using BALB/C mice (Rappolovo nursery). The immunostimulating activity of the polymer was estimated by its influence on the appearance of antibody-forming cells to sheep red blood cells by the local hemolysis method in gel. A strong dependence of the antibody response on the polymer molecular mass was observed. The maximum activity was manifested for PNVF with molecular masses in the range (55 – 85) × 103.