Structural Biology in Use : NMR, X-ray and Molecular DynamicsModeling in Study on Multistep Phosphorelay Signaling in Plants
2014
In multistep phosphorelay (MSP) pathway, the His-containing
phosphotransmitters encoded by AHP genes in Arabidopsis act as
signaling intermediates integrating signaling inputs from
diverse sensor histidine kinases In comparison to prototypical
two-component signaling in bacteria displaying high level of
specificity, the level of specificity in related plant MSP
signaling remained unclear Here I will describe our results
employing both experimental and computational approaches in the
identification of structural determinants of specificity in MSP
signaling in Arabidopsis
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