Pharmacokinetics of Oxiracetam in Healthy Volunteers

Aim To study the pharmacokinetics of oxiracetam a ft er single and multiple intravenous administrations in healthy volunteers. Method A HPLC method was used to determine the serum concentration of oxiracetam after intravenous single dose and daily dose of 2 000 mg for 7 d in ten Chinese healthy volunteers. Pharmacokinetic analysis was carried out using D rug And Statistic software. Results The AUC 0-12, AU C 0-∞, K e, t 1/2, MRT after a single dose of 2 000 mg oxiracetam were 256.26±16.84 μg·mL -1·h, 276.74±18.11 μg·m L -1·h, 0.18±0.03 h -1, 3.84±0.64 h, and 4.39±0.39 h, and after multiple doses of oxiracetam were 259.36±25.43 μg·mL -1·h, 285 .59±27.38 μg·mL -1·h, 0.17±0.04 h -1, 4.14±0.82 h, and 4 .87±0.69 h, respectively. Conclusion The pharmacokinetic p arameters of oxiracetam do not differ remarkably after single and mult iple intraven ous administration and there is accumulation in serum after 2 000 mg multip le intravenous administration once a day for 7 d.