[Impact of chronic prostatitis/chronic pelvic pain syndrome on sperm DNA fragmentation and nucleoprotein transition].

Objective: To investigate the impact of chronic prostatitis / chronic pelvic pain syndrome( CP/CPPS) on sperm DNA fragmentation and nucleoprotein transition. Methods: Based on the recommended methods in the WHO Laboratory Manual for the Examination and Processing of Human Semen( 5th ed),we conducted routine semen analysis for 65 CP / CPPS patients and 30 healthy men. We also analyzed the results of papanicolaou staining,sperm DNA fragmentation and sperm nucleoprotein transition. Results: Compared with the healthy control males,the CP / CPPS patients showed significant decreases in sperm concentration( [134. 05 ± 99. 80]vs [94. 75 ± 92. 07]) × 106/ ml,P 0. 05),the percentage of morphologically normal sperm( [7. 26 ± 2. 28]vs [5. 61 ± 3. 40]%,P 0. 05) and sperm progressive motility( [59. 18 ± 16. 06]vs [47. 68 ± 17. 62]%,P 0. 05),but dramatic increases in sperm DNA fragmentation( [22. 92 ± 11. 51]vs [43. 58 ± 17. 07]%,P 0. 01) and sperm nucleoprotein transition( [23. 26 ± 5. 97]vs [32. 14 ± 8. 79]%,P 0. 01). Conclusion: CP / CPPS significantly reduces sperm quality and male fertility.