New insights into the functions of Ptd Ins（3,5）P_2 in the pathogenisis of neurodegenerative disorders

The membrane trafficking systems in brain play an important role in the regulation of neuronal processes,such as morphology,neuronal survival and synaptic plasticity.It has been suggested that the phosphatidylinositols(PIs)located on endolysosomal membranes play a key role in controlling this trafficking systems.Recently,we have reported that Ptd Ins(3,5)P2,which is