Pyridinones replaced as modulators of p38 MAP kinase.

A compound of the formula: ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein R5 is heteroaryl or heteroarylalkyl, wherein the heteroaryl and heteroaryl groups are optionally substituted with 1, 2, 3 or 4 groups that are independently -C (O) NR6R7, - (C1-C4 alkyl) -C (O) NR6R7, -NR6R7, hydroxy (C1-C4), dihydroxy C1-C4 alkyl, H, OH, halogen, haloalkyl, alkyl, haloalkoxy, R6R7N- (C1-C6) -, -CO 2 (C1-C6), -N (R) C (O) NR6R7, or -N (R) C (O) -alkoxy (C1-C6 ); or R5 is ** (See formula) ** X1 is independently selected from -C (O) NR6R7, - (C1-C4 alkyl) -C (O) NR6R7, -NR6R7, hydroxy (C1-C4), dihydroxy C1 C4 alkyl, OH, halogen, haloalkyl, alkyl, haloalkoxy, heteroaryl, heterocycloalkyl, C3-C7 cycloalkyl, R6R7N- (C1-C6) -, -CO 2 (C1-C6), -N (R) C (O ) NR6R7, -N (R) C (O) -alkoxy (C1-C6), CO2R- (C1-C6) - or -SO2NR6R7; wherein the heteroaryl and heterocycloalkyl groups are optionally substituted with -NR6R7, -C (O) NR6R7, R6R7N- (C1-C6) -, C1-C6 alkyl, C1-C6 alkoxy or halogen; X2, Xa, Xb, Xc, Xd and Xe are independently selected from -C (O) NR6R7, - (C1-C4 alkyl) -C (O) NR6R7, -NR6R7, hydroxy (C1-C4), dihydroxy C1-C4 alkyl, H, OH, halogen, haloalkyl, alkyl, haloalkoxy, heteroaryl, heterocycloalkyl, C3-C7 cycloalkyl, R6R7N- (C1-C6) - alkyl, -CO 2 (C1-C6), -N (R) C ( O) NR6R7, -N (R) C (O) -alkoxy (C1-C6), CO2R- (C1-C6) - or -SO2NR6R7; where the heteroaryl and heterocycloalkyl groups are optionally substituted with -NR6R7, -C (O) NR6R7, R6R7N- (C1-C6) -, C1-C6 alkyl, C1-C6 alkoxy or halogen; Y, Y1, Y2, Y3, Y4 and are independently selected from H, halogen, alkyl, carboxaldehyde, hydroxyalkyl, dihydroxyalkyl, alkenyl, alkynyl, CN, alkanoyl, alkoxy, alkoxyalkyl, haloalkyl, and carboxyl; R6 and R7 are independently at each occurrence, H, C1-C6 alkyl, C1-C6 alkyl, C1-C6 C1-C6 alkyl, C1-C6 alkoxycarbonyl, OH, hydroxy C1-C6 alkyl, dihydroxy C1-C4 alkyl , thiohydroxy C1-C6 alkyl, -C (C1-C4) -CO 2 -alkyl, pyridyl C1-C6 alkyl, C1-C6 alkanoyl, benzyl, phenyl C1-C6 or C1-C6 phenylalkanoyl, wherein each of the aforementioned is unsubstituted or substituted with 1, 2 or 3 groups that are independently halogen, C3-C6 cycloalkyl, C1-C6 alkoxy, piperidinyl C1-C6 alkyl, morpholinyl C1-C6 alkyl, piperazinyl C1-C6 alkyl, OH, SH, NH2, NH (alkyl), N (alkyl) (alkyl), -O-C1-C4 alkanoyl, C1-C4 alkyl, CF3 or OCF3; or R6, R7 and the nitrogen to which are attached form a morpholinyl, thiomorpholinyl, piperidinyl, pyrrolidinyl or piperazinyl is optionally substituted with 1 or 2 groups that are independently C1-C4 alkyl, C1-C4 alkoxy, hydroxy, hydroxy C1- C4, C1-C4 dihydroxyalkyl, or halogen; and R, at each occurrence, is independently H or C1-C6 alkyl.