Hedgehog inhibition impaired platinum response in high-grade serous ovarian cancer harboring high hedgehog ligand expression and mTOR pathway activation.

Gwo-Yaw Ho,Elizabeth Lieschke,Elizabeth Kyran,Kristy Shield-Artin,Olga Kondrashova,Holly Barker,Robert Hollian,Aurélie Cazet,Thuan Phuong,Alexander Swarbrick,Orla McNally,David Bowtell,Matthew J. Wakefield,Clare L. Scott

Hedgehog inhibition impaired platinum response in high-grade serous ovarian cancer harboring high hedgehog ligand expression and mTOR pathway activation.

2017

Gwo-Yaw Ho
Elizabeth Lieschke
Elizabeth Kyran
Kristy Shield-Artin
Olga Kondrashova
Holly Barker
Robert Hollian
Aurélie Cazet
Thuan Phuong
Alexander Swarbrick
Orla McNally
David Bowtell
Matthew J. Wakefield
Clare L. Scott

5583Background: Elevated Glioma-associated Oncogene Homolog-1 (Gli1) protein expression is associated with Hedgehog (Hh) pathway activation in high-grade serous ovarian cancer (HGSOC). Inhibition o...

Keywords:

PI3K/AKT/mTOR pathway
Ovarian cancer
Hedgehog
Pathology
Cancer research
Serous fluid
Medicine
GLI1
serous ovarian cancer
Oncogene
Ligand
Protein expression

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