Immune memory in nonclinical models after treatment with NKTR-214, an engineered cytokine biased towards expansion of CD8+ T cells in tumor.

Deborah H. Charych,Werner Rubas,Vidula Dixit,Janet Cetz,Rhoneil Pena,John L. Langowski,Ute Hoch,Murali Addepalli,Stephen Doberstein,Jonathan Zalevsky

Immune memory in nonclinical models after treatment with NKTR-214, an engineered cytokine biased towards expansion of CD8+ T cells in tumor.

2016

Deborah H. Charych
Werner Rubas
Vidula Dixit
Janet Cetz
Rhoneil Pena
John L. Langowski
Ute Hoch
Murali Addepalli
Stephen Doberstein
Jonathan Zalevsky

11545Background: NKTR-214 is an immune-stimulatory cytokine designed to provide a controlled, sustained, and CD122-biased receptor signal through the heterodimeric IL2 receptor pathway (IL2Rbg) res...

Keywords:

Pathology
Immune system
Cytotoxic T cell
Cytokine
Immunology
Medicine
after treatment
IL-2 receptor
Receptor
immunological memory

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