The synthetic method of the amides compound that a kind of phosphorus oxychloride promotes

The present invention relates to the synthetic method of the amides compound that a kind of phosphorus oxychloride promotes.The synthetic method of the present invention is with carboxylic acid for a wherein reactant, with another reactant (N, N dialkylformamide) for solvent, adds the phosphorus oxychloride of 1 equivalent, prepares amide compound.Reaction substrate is cheap and easy to get, and stable in properties, toxicity are little, are swift in response, mild condition, and the substrate of different functional groups is had wide applicability.The amides compound that the present invention efficiently builds is the important molecule skeleton of a lot of medicine, bioactive molecule and natural product, and synthetic method of the present invention is that the synthesis of this compounds provides a generally applicable preparation method.