Open-Label, Observational Pilot Study Evaluating Desoximetasone Topical Spray 0.25% Twice Daily in Patients With Psoriasis Being Treated With Biologic Agents:

Biologic therapy has been an important addition to the armamentarium of psoriasis drugs as they offer high efficacy with a better side effect profile than systemic agents. However, there are cases in which patients do not respond rapidly or lose their initial response to biologic therapy, thus requiring additional treatment. While biologic therapy could be switched from one agent to another, in many cases, patients have had no adverse events (AEs) and the remaining lesions are minimal. In such cases, the addition of a topical agent may be the best choice. This single-center, open-label observational study enrolled 20 patients ≥18 years of age with plaque psoriasis with ≤5% body surface area (BSA) involvement. Patients received biologic therapy for at least 24 weeks prior to baseline. Topical combination therapy with desoximetasone spray 0.25% was added twice daily for 4 weeks and then decreased to twice-daily application on 2 consecutive days per week to week 16. Topical therapy was effective and well tol...