Multi-scale investigation of Alzheimer’s disease brain tissue using 1060 nm swept source optical coherence tomography (Conference Presentation)

We demonstrate imaging of amyloid-beta plaques in ex-vivo Alzheimer’s disease brain tissue using a 1060 nm swept source optical coherence tomography setup. This instrument enabled a global investigation of the brain tissue with a large field of view of 8 mm x 8 mm as well as sequential high resolution imaging. Amyloid-beta (A-β) plaques were identified as highly scattering features. Results were in good agreement with immunohistochemically stained images gained by histology.