Preparation method of amorphous atorvastatin calcium

2016 
The invention discloses a preparation method of amorphous atorvastatin calcium, which comprises the steps of dissolving atorvastatin calcium in any crystal form in an organic solvent, stirring till complete dissolution; after distilling off a part of organic solution by a distillation drying method, adding absolute ether to continue distillation till all the solvent is removed, thereby obtaining amorphous atorvastatin calcium. The method greatly shortens process time, has lower vacuum requirements on reduced pressure distillation and low requirements on industrial equipment and is suitable for industrial production.
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