Phosphorus–Nitrogen Compounds XV: N-1-Adamantylphosphoramidic Dichloride and Dimethyl and Diphenyl N-1-Adamantylphosphoramidate

N-1-Adamantylphosphoramidic dichloride and the dimethyl and diphenyl esters of the corresponding acid were synthesized and evaluated for biological activity. The dimethyl ester delayed the onset of tremorine-induced tremors and reduced locomotor activity, while the diphenyl derivative slightly antagonized perphenazine-induced catatonic reactions. None of the agents displayed activity against lymphoid leukemia.