Facial Rejuvenation in the Triangle of ROS

Recently, we introduced into the conventional catalogue of biological aging a new determinant: ordered interfacial water layers. The discovery of their tunability with skin-tolerated levels of 670 nm light inspired a model, which suggested that the light, by interaction with ordered interfacial water layers in the extracellular matrix, would reverse elastin degeneration. We validated the model in a 10 month self-experiment and arrived at an effective facial rejuvenation program. Importantly, during the experimental phase we avoided extreme oxidative stressors, in particular exposure to extensive ultraviolet and infrared radiation as well as air pollution. Here we report on the adaptation of our model to the extreme oxidative stress levels prevalent in numerous polluted megacities. The results of the extension comprise a new understanding of the protective function of the skin acid mantle, new predictive insight into effects of reactive oxygen species (ROS) on interfacial water layers, and their implicatio...