Corticotropin releasing hormone promoter region polymorphisms in rheumatoid arthritis.

The regulation of the human corticotropin releasing hormone (CRH) gene is of interest since it mediates the interaction of stress events and inflammatory signals on the hypothalamo-pituitary-adrenal axis. Patients with rheumatoid arthritis (RA) have impaired CRH response to stress so that polymorphisms in the 5' regulatory region of the CRH gene could be responsible for decreased CRH responsiveness. To examine whether patients with RA have polymorphisms of the regulatory region of CRH, we amplified fragments of the 3.7 kb genomic DNA from 5 unrelated patients with RA and 2 controls. DNA sequencing revealed 3 nucleotide variants. These variants have been characterized as a T

Keywords:

• Gene expression
• Restriction fragment length polymorphism
• Genotype frequency
• Restriction enzyme
• Gene
• Genetics
• Corticotropin-releasing hormone
• Allele
• Promoter
• Biology
• Consensus sequence

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