Palladium-Catalyzed Oxidative Intramolecular CC Bond Formation via Double sp2 CH Activation between the 2-Position of Imidazoles and a Benzene Ring

Oxidative intramolecular CC bond formation via double sp2 CH activation between the 2-position of imidazoles and a benzene ring catalyzed by palladium(II) has been developed, which provides an atom-economical, concise and efficient methodology to synthesize imidazole- or benzimidazole-fused isoquinoline polyheteroaromatic compounds.