TETRAHYDROTHIENOPYRIDINE DERIVATIVES AS NOVEL GPIIB/IIIA ANTAGONISTS

Kiyoaki Katano,Eiki Shitara,Masaro Shimizu,Kazue Sasaki,Tomoaki Miura,Yasuko Isomura,Mami Kawaguchi,Shokichi Ohuchi,Takashi Tsuruoka

TETRAHYDROTHIENOPYRIDINE DERIVATIVES AS NOVEL GPIIB/IIIA ANTAGONISTS

1996

Kiyoaki Katano
Eiki Shitara
Masaro Shimizu
Kazue Sasaki
Tomoaki Miura
Yasuko Isomura
Mami Kawaguchi
Shokichi Ohuchi
Takashi Tsuruoka

Abstract The tetrahydrothienopyridine derivatives were derived from aminomethylcyclohexylcarboxylic acid as a lead moiety. Evaluation of the antiplatelet activity and receptor binding assay revealed that compound 1 (ME3277) was a novel and potent non-peptide and non-amidinophenyl GPIIb/IIIa antagonist.

Keywords:

GpIIb/IIIa
Antagonist
Combinatorial chemistry
Moiety
Ligand (biochemistry)
Stereochemistry
Chemistry
gpiib iiia antagonist

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