Method for synthesizing liraglutide
2016
The present invention provides a method for synthesizing liraglutide, comprising the steps of: obtaining a dipeptide fragment, a tripeptide fragment, a tetrapeptide fragment, and/or a pentapeptide fragment; obtaining Fmoc-Gly-resin; coupling the dipeptide fragment, the tripeptide fragment, the tetrapeptide fragment, and the pentapeptide fragment or a combination thereof to an amino acid and the Fmoc-Gly-resin, so as to obtain liraglutide resin; and performing side-chain modification and then pyrolysis, or directly performing pyrolysis, purifying, and freeze-drying, so as to obtain liraglutide.
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