A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis.

Jennifer Bridwell-Rabb,Aoshu Zhong,He G. Sun,Catherine L. Drennan,Hung Wen Liu

A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis.

2017

Jennifer Bridwell-Rabb
Aoshu Zhong
He G. Sun
Catherine L. Drennan
Hung Wen Liu

The biosynthesis of oxetanocin A involves OxsB, a B12-dependent S-adenosylmethionine radical enzyme, which catalyses an unusual ring contraction of a 2′-deoxyadenosine phosphate.

Keywords:

Enzyme
Metalloprotein
Radical SAM
Biosynthesis
Biochemistry
Organic chemistry
Phosphate
Chemistry
DNA
Active site
Cofactor
Gene cluster
Stereochemistry

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