Dynamics of celiac disease-specific serology after initiation of a gluten-free diet and use in the assessment of compliance with treatment

Abstract Background The usefulness of celiac disease-related serology in monitoring patients on a gluten-free diet has been debated. Aim To describe serologic changes over time and assess whether serology tests can predict compliance with the gluten-free diet. Methods Sera obtained at baseline and every 3 months thereafter for 1 year in 82 adult celiac disease patients were assayed for: (1) IgA antigliadin, (2) IgA anti-tissue transglutaminase, (3) IgA endomysial, (4) IgA, and (5) IgG anti-deamidated gliadin peptides, (6) dual detection of IgA and IgG anti-deamidated gliadin peptides, (7) a single assay for IgA and IgG of both anti-deamidated gliadin peptide and anti-tissue transglutaminase, and (8) IgA antiactin antibodies. Results At 3 months after diagnosis, most antibody assays significant decrease in mean concentrations ( p p p p p p p Conclusions Gluten-free diet treatment produced rapid and significant qualitative and quantitative changes in celiac disease-related antibodies which may be useful for monitoring dietary compliance.