Synthesis and biological evaluation of pyrimidinyl sulphonamide derivatives as promising class of antitubercular agents

Abstract A small library of compounds are synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37RV. Two compounds, -[(2′,4′-dinitrophenyl)sulphonyl]-4-(p-aminophenylsulphonylamino)-6-(2′-chlorophenyl)-pyrimidine-5-carboxamide F b and 2-hydrazino-4-(p-aminophenylsulphonylamino)-6-(2′-chlorophenyl)-pyrimidine-5-carboxamide D b were found to be the most active compounds in vitro with MIC of 0.02 μg/mL against MTB and were more potent compared to isoniazid (MIC: 0.03 μg/mL).