Ultrasonic particle size reduction of radiolabeled pharmaceuticals

High-intensity ultrasonic treatment of MeOH/H2O, IPA/H2O, EtOH or H2O suspensions of C-14 labeled and unlabeled pharmaceuticals successfully reduced the average particle diameter from a range of 8–260 to 4–15 µm as determined by optical microscopy. Copyright © 2004 John Wiley & Sons, Ltd.