Anti-inflammatory Signaling in Microglia Exacerbates Alzheimer’s Disease-Related Pathology
2015
In this issue of Neuron , Chakrabarty et al. (2015) and Guillot-Sestier et al. (2015) reveal that the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive decline in mouse models of Alzheimer's disease (AD). These studies provide further support that pro-inflammatory signaling is an innate immune defense mechanism in AD.
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