BIOLOGÍA MOLECULAR DE LAS METÁSTASIS ÓSEAS

Resumen.- Las metastasis oseas son complicaciones frecuentes y a menudo desvastadoras de los pacientes con cancer. Recientemente se han producido avances significativos en nuestra comprension de los mecanis-mos moleculares responsables de metastasis tanto os-teoliticas como osteoblasticas. El uso de las “OMICAS” y la disponibilidad de modelos animales preclinicos de metastasis oseas adecuados han permitido la identifi-cacion de los factores producidos por el tumor o por @ CORRESPONDENCIAAndreas DollResearch Unit in Biomedicine andTranslational and Pediatric Oncology Research Institute Vall d’Hebron University Hospital Pg. Vall d’Hebron 119-12908035 Barcelona (Espana)andreas.doll@vhir.org Palabras clave: Cancer de prostata. Metastasis oseas. Biologia molecular.Summary.- Bone metastases are a frequent and devastating complication in cancer patients. Recently, significant advances in our understanding of the mole-cular mechanisms responsible for both osteolytic and osteoblastic bone metastases have occurred. The use of OMICS and the availability of appropriate preclini-cal animal models of bone metastasis have permitted the identification of factors produced by the tumor or by the host stroma in response to the tumor. These types of studies should result in a decrease of the serious skeletal morbidities associated with metastatic prostate cancer and may in the future improve overall survival. In this review the next generation of molecular targets in bone metastasis will be summarized.