Kinetic recognition of the 5′-phosphate group in the attack of cisplatin-type systems on DNA

Mathematical models have been constructed to describe the kinetics of formation of cis-[Pt(NH3)2{d(‥pApGp‥)}] and cis-[Pt(NH3)2{d(‥pGpGp‥)}] from DNA and cisplatin-type systems; the rate constant and entropy of activation of the initial reaction with G indicate that the 5′-phosphate is very important kinetically.