Ribavirin small-capacity injection preparation and preparation method thereof

2013 
The invention discloses a ribavirin small-capacity injection preparation. The ribavirin small-capacity injection preparation comprises the following components in percentage by weight: 5%-15% of ribavirin, 1%-4% of anodyne, 0.01%-0.03% of active carbon, and water being supplemented to 100% by weight, wherein the pH value is regulated to 5.0-6.0 by a buffer solution. The invention further discloses a preparation method of the ribavirin small-capacity injection preparation. The ribavirin small-capacity injection preparation is detected and checked by regulating the dosage ratio of the anodyne, active carbon and the buffer solution in the prescription, and carrying out primary filtration, intermediate filtration and refined filtration by adopting a titanium rod filter, a 0.65-micron polypropylene filter core and a 0.22-micron polyether sulfone filter core in sequence, so that the defects of large primary medicine consumption and low percent of pass during the preparation process of the ribavirin small-capacity injection preparation are effectively solved. Besides, the prescription is simple, the yield is high, the clinical application is safe, the pain feeling is small, and the large-scale industrial production is convenient.
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