Activated protein C suppresses adrenomedullin and ameliorates lipopolysaccharide-induced hypotension

ABSTRACTActivated protein C (APC) is an important modulator of vascular function that has antithrombotic and anti-inflammatory properties. Studies in humans have shown modulation of endotoxin-induced hypotension by recombinant human APC, drotrecogin alfa (activated), however, the mechanism for this