Paromomycin-associated pancreatitis in HIV-related cryptosporidiosis.

Objective:To report a case of pancreatitis related to paromomycin administration.Case summary:A 39-year-old man with AIDS developed pancreatitis concurrent with successful treatment of intestinal cryptosporidiosis with paromomycin. The hyperamylasemia resolved with discontinuation of the agent and recurred when paromomycin treatment was reinstituted.Discussion:To our knowledge, this is the first reported case of pancreatitis believed to be induced by paromomycin. Although pancreatitis in HIV-infected patients has multiple causes, the nature of this case suggests the involvement of paromomycin. The mechanism of action is unclear.Conclusions:Pancreatitis should be considered in the differential diagnosis of abdominal pain in patients who are treated with paromomycin.