A CLINICAL COMPARATIVE STUDY OF EFFECT OF PROPOFOL, ETOMIDATE AND COMBINATION OF PROPOFOL AND ETOMIDATE ON ATTENUATION OF HAEMODYNAMIC RESPONSE TO ENDOTRACHEAL INTUBATION

Aim and objective: The aim of this study was to compare the effect of  Propofol and Etomidate separately and in a combination with  reduced doses of the two drugs in attenuating the hemodynamic response following laryngoscopy and intubation. Methods: After taking ethical committee clearance, A prospective randomized double blinded study involving 90 patients aged 18-60 years of either sex and ASA physical status I or II scheduled for elective surgery under general anesthesia were randomly placed into three groups. Group A induced with Inj.Propofol (2.5 mg/kg), Group B with Inj.Etomidate (0.3 mg/kg) and Group C with Inj.Propofol (1.5 mg/kg) plus Inj.Etomidate (0.15 mg/kg). Heart rate (HR), mean arterial pressure (MAP) were recorded at baseline, after induction, before intubation, immediately after intubation and then at 1min, 3 min, 5 min and 10 min. ANNOVA and chi-square test were used for statistical analysis. Result: Heart rate in all study groups decreases after induction and it was more in group A compared to group C (p<0.045) and after intubation HR increases in all three groups but this increase was greater in group B than A and C (p˂0.000, p˂0.001). MAP among all three groups decreases after induction and it was more in group A than group B and C (p˂0.000, p˂0.000). MAP was increased after intubation in all groups, more in group B than A and C(p˂0.000,p˂0.010). Conclusion: The combination of propofol plus Etomidate has better hemodynamic stability than propofol and etomidate alone.