Fabrication of rifampicin microcapsules with a polylactide shell

Procedure for encapsulation of rifampicin by evaporation of a volatile solvent was developed. An effective stabilizer making it possible to reach a 23% incorporation of the main substance into capsules was selected. The basic microcapsule parameters (particle size distribution, degree of polydispersity, and electrokinetic potential) were determined. The kinetics of rifampicin release from microcapsules was examined.