Nichtestrogene derivatives of oestradiol having antioxidative activity

New non-estrogenic estradiol derivatives with an antioxidant effect are disclosed. These estradiol derivatives, which have no estrogenic effect but a high antioxidant effect, are potentially useful as non-estrogenic antioxidants, in particular for postmenopausal women and for men. Moreover, the disclosed compounds are potential aromatase and sulfatase inhibitors.