Microcavity Array Supported Lipid Bilayer Models of Ganglioside - Influenza Hemagglutinin1 Binding

Microcavity supported Lipid Bilayers (MSLBs) are demonstrated as versatile platforms for modelling unit steps in viral-membrane interactions. The binding of influenza receptor (HA1) to membranes containing different glycosphingolipid receptors was investigated. We observed that HA1 preferentially binds to GD1a but the diffusion coefficient of the associated complex at lipid bilayer is approximately double that of the complexes formed by HA1 GM1 or GM3.