Electroanalytical detection of amlodipine in urine and pharmaceutical samples using Ag-Ce2(WO4)3@CNF nanocomposite-modified glassy carbon electrode

Abstract A novel, simple, and convenient electroanalytical method for the detection of Amlodipine (AMD) has been investigated via an electro-oxidation mechanism using silver-cerium tungstate decorated carbon nanofiber (Ag-Ce2(WO4)3@CNF) nanocomposite by differential pulse voltammetry (DPV) for the first time. Ag-doped Ce2(WO4)3 decorated CNF was constructed by using simple hydrothermal followed by ultrasonication methods. The synthesized ternary nanocomposite was characterized by using FT-IR, X-Ray Diffraction, Raman spectroscopy, SEM with EDX, and TEM analysis. The Ag-Ce2(WO4)3@CNF modified GCE shows an excellent electrocatalytic response towards the oxidation of AMD in 0.05 M of PBS (pH 7) compared to Ag and Ag-Ce2(WO4)3 modified electrodes. The AMD detection limit is found to be 0.712 nM with a linear range of 0.01-130 μM. The electrocatalytic property of the ternary nanocomposite of electrochemical sensing of AMD in different real samples (human urine and pharmaceutical drug) has been investigated and achieved tremendous recovery. The fabricated sensor also shows good selectivity, reproducibility, and long-time stability. Hence, this ternary nanocomposite could be open a new platform in biomedical applications.