EFFECTS OF CDDP, ADR, CPT-11 ON RATS WITH ENNG-INDUCED GASTROINTESTINAL CARCINOGENESIS

Effects of Cisplatin (CDDP), Adriamycin (ADR) and a new derivative of camptothecin (CPT-11) on rats with ENNG-induced gastrointestinal carcinogenesis were studied through the survival rate, incidence and cell kinetic analysis. The 12-month survival rate was better in the groups treated with CDDP, ADR and CPT-11 than in the control. The incidence of carcinogenesis in the CDDP and ADR groups was 38% and 33%, respectively, which were significantly (p<0.05) lower than 88% in the control group. The incidence (86%) of carcinogenesis in the CPT-11 group was not different from that (88%) of the control group. However, the number of tumors per rat and the mean largest diameter and weight of tumors were lower in the CPT-11 group than the other groups, suggesting its higher antitumor effect. In cell kinetic analysis, the rate of S-phase cells of the mucosa without tumor was significantly (p<0.01) lower in the groups treated with CDDP, ADR and CPT-11 than in the control. The anti-tumor drugs showed the suppressive effect of carcinogenesis by acting on the normal epithelium level. Carcinogeneticlesions was also significantly (p<0.01) lower in the groups treated with CDDP, ADR and CPT-11 than in the control. We conclude that CDDP, ADR and CPT-11 have suppressive effects of carcinogenesis and anti-tumor effects on rats with ENNG-induced gastrointestinal carcinogenesis.